How Does Kratom Work? is a common question asked by new users of the plant-based supplement. Kratom contains 40 biologically active compounds that act on opioid receptors in the brain. In the short term, these compounds act to relieve pain and symptoms of anxiety, depression, and cravings. However, there is more to this plant than just its ability to relieve pain. Kratom is also beneficial in treating various physical conditions.

Kratom Is A Plant-Based Supplement

Although it is legal in some states, the FDA and some counties have banned the use of kratom. More than a dozen countries, including the United States, Canada, Japan, and Russia, have banned the use of kratom, citing the potential for harmful health effects. Because of these concerns, most users of kratom are white, educated, middle-aged, and male. About 1.5% of users were Native American, Asian, or African American.

The kratom powders have been used to treat many different conditions, including opioid withdrawal and mood disorders. In addition, they have been used to treat withdrawal symptoms from prescription and illicit drug use. The most common way to consume kratom is in the form of powder mixed into a beverage or in pill form. According to Oliver Grundmann, clinical associate professor of medicinal chemistry at the University of Florida, kratom is safe in moderation.

Studies Show That Kratom Acts On Opioid Receptors In The Brain

This interaction can alleviate pain and overcome opioid addiction. While many medical communities discourage the use of opioids in treating pain, kratom offers a compelling alternative that produces similar effects. In addition, because kratom is considered a natural, plant-based supplement, it does not carry the negative stigma associated with narcotics.

Kratom Contains Over 40 Biologically Active Compounds

The most abundant compound in Kratom is 7-Hydroxymitragynine, which has a potency 17 times that of morphine. However, the entire plant contains more than 40 biologically active compounds. The amount of each alkaloid in cheap kratom capsules varies, and the dosage that you take will depend on the effects you are seeking. This leaf has dozens of alkaloids, with two dominant compounds Mitragynine and 7-HMG, Ajmalicine, and Mitragynine. The balance and total concentration of each drug in Kratom will be dependent on how it is processed.


This compound has opioid-like effects and inhibits prostaglandin E2 production. It also interacts with the norepinephrine and serotonin systems. Mitragynine is an effective anxiolytic in animal behavioral models. However, it has been found that 7-HMG has a greater opioid receptor stimulating effect than mitragynine.


The alkaloids in Kratom are metabolized in the body, and can be detected using regular chromatographic and spectroscopic methods. DNA sequences from kratom can help to determine the exact composition of kratom. Alternatively, thin-layer chromatography on silica gel plates can be used to separate alkaloids. When sprayed with Ehrlich’s reagent, mitragynine gives a purple or gray-brown color.

Moreover, the alkaloids in kratom possess several structural similarities with other opioids. This allows them to bind to multiple receptors, and mitragynine has the highest affinity for mu opioid receptors. While testing these compounds would be costly, the in-silico binding profiles generated by PHASE allow researchers to prioritize the most promising compounds and focus experimental study efforts on those with the highest risk.

It Affects Opioid Receptors In The Brain

Scientists at the Food and Drug Administration (FDA) have studied the chemical structure of 25 compounds in kratom, including mitragynine, and concluded that the substance has many similarities to controlled opioid analgesics. They also ran these chemical structures through a software program that predicts likely biological targets. In fact, the scientists predicted that 22 of the 25 compounds would bind to mu-opioid receptors. This hypothesis was confirmed when the group discovered that two of the top five kratom compounds activated opioid receptors.

Despite the risks of kratom, many people use it as a self-medication to combat various conditions, including anxiety, depression, and post-traumatic stress disorder. The compounds in kratom act on opioid receptors in the brain and interact with the serotonin and adrenaline receptors. While the DEA does not specifically prohibit the use of kratom, it does warn that it should be used with care.

The effects of kratom in mice are not entirely clear, however. Interestingly, high-dose mitragynine appears to affect spatial learning and the ability to perform long-term potentiation in the CA1 field of the rat hippocampus. Although the exact neural mechanisms that lead to adverse cognition remain unclear, this drug has been shown to impair self-administration and reestablish addiction in rodents.